Plagued by a violent recurring nightmare, college student Stefanie heads home to track down the one person who might be able to break the cycle and save her family from the grisly demise that inevitably awaits them all.

Twenty-eight years since the rage virus escaped a biological weapons laboratory, now, still in a ruthlessly enforced quarantine, some have found ways to exist amidst the infected. One such group lives on a small island connected to the mainland by a single, heavily-defended causeway. When one member departs on a mission into the dark heart of the mainland, he discovers secrets, wonders, and horrors that have mutated not only the infected but other survivors as well.

Taking place during the events of John Wick: Chapter 3 – Parabellum, Eve Macarro begins her training in the assassin traditions of the Ruska Roma.

After the underlying tech for M3GAN is stolen and misused by a powerful defense contractor to create a military-grade weapon known as Amelia, M3GAN's creator Gemma realizes that the only option is to resurrect M3GAN and give her a few upgrades, making her faster, stronger, and more lethal.